I think that both of you guys may have over-analyzed the question. Looking at his other comments, I am a bit suspicious that the situation here is that OP has USB headphones and is concerned about using the USB cable that came with his mouse versus the USB cable that came with his headphones (for which the cables are almost certainly totally interchangeable).

This is in no way to detract from your answers, which are an interesting take on throwing audio connectors on USB cables and running analog audio signals over them. Just that I think that what he’s asking is much simpler than the question that you’re answering.