https://www.eurasiantimes.com/a-whopping-900b-debt-chinas-once-profitable-high-speed-railways/?amp

It’d be good to have high speed rail but not at any cost.

Queue tankies going crazy to defend the absurd cost…

Why didn’t they simply make the car cheaper without software locking features?

Seems like a bit of a lousy move on the part of Tesla

Good review by Mortismal Gaming:

https://youtube.com/watch?v=8h64EYMoLF8&feature=share9

This guy specialises in reviewing CRPGs and his reviews are really good. Often he reviews games after 100% completing them

I’ve only completed Act I and can’t believe Act II will be even bigger, there’s already so much to do in Act I. Are there only two acts in total? After DOS2 I plan on playing through Pathfinder Wrath of the Righteous and then maybe Pillars of Eternity 2

Did you help Slane the dragon?

Also that, according to the WHO, processed meat is carcinogenic and red meat is probably carginogenic so people are giving themselves cancer by eating it.

Source:

https://www.who.int/news-room/questions-and-answers/item/cancer-carcinogenicity-of-the-consumption-of-red-meat-and-processed-meat

Why a cure for ageing would benefit everyone and not solely the ultra wealthy

If you put aside ethical and humanitarian reasons for making a cure for ageing widely available, there is still economic considerations, i.e. if you are a government you will be presented with a choice between:

Do I pay to treat people for ageing, even though the treatment might initially be expensive, or do I let them age without intervention?

The former option might actually be significantly cheaper because people in an advanced state of ageing cost more money. They have more diseases, since many diseases are age related such as dementia, cancer and cardiac disease, and need more healthcare and also can’t work anymore.

If instead, the government pays for rejuvenation treatment they save on all the other healthcare costs and their people don’t have to stop being productive.

So perhaps in the future when a cure for ageing is actually developed it will be made available for everyone rich and poor alike

“Thus, rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means.”

https://doi.org/10.18632/aging.204896

– Journal of Aging

Full journal article here

https://www.aging-us.com/article/204896/text

“Thus, rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means.”

– Journal article abstract

The full journal article says “in vivo” not “in vitro”. They have already successfully regenerated mice which are organisms biologically similar to humans.

Edit

I was wrong about this. The journal article does only talk about results obtained “in vitro” but mentions other studies that have successfully reversed cellular ageing “in vivo”.

The ability of the Yamanaka factors to erase cellular identity raised a key question: is it possible to reverse cellular aging in vivo without causing uncontrolled cell growth and tumorigenesis? Initially, it didn’t seem so, as mice died within two days of expressing OSKM. But work by the Belmonte lab, our lab, and others have confirmed that it is possible to safely improve the function of tissues in vivo by pulsing OSKM expression [22, 23] or by continuously expressing only OSK, leaving out the oncogene c-MYC

So in this study the results were only in vitro but other studies have successfully reversed cellular ageing in vivo.

Can’t wait for this to be released. IIRC a lot of it was built in the rust programming language which is a bit of interesting trivia