I love this wallet incorporates monero mining, it’s a simple yet awesome approach!

So Ubuntu has a version called Lubuntu, which used to come with LXDE, but now it comes with LXQt. So this will require you to install LXDE with the tasksel command, unless you start with Ubuntu desktopless. But I’d say to definitely check out Kubuntu, it’s the KDE version, and I feel like KDE and LXDE are quite similar. Both have an older windows overall appearance.

Ever pop your ears when going up a mountain or during flight? This is air pressure changes. Either way, water tight does not mean air tight, while air tight does mean water tight assuming the material is not water soluble.

I have yet to see it, but in addition to the lackluster reddit thread, here are the IMDB reviews: https://imdb.com/title/tt16283824/reviews

While IMDB has rated a number of films/shows I love well lower than I feel they should be, all in all the scores tend to be a pretty good indicator. They rated it 7/10 with some folks ranting and raving about it, while others say the show tried to fit too much into it. Hope this is at least somewhat helpful.

Good on you for being so knowledgeable about the disorder. But 100% ask your doc, being real with my doc has taken our appointments to the next level. The genome is only half of the IgE allergy response, other half is the environment you were raised in as you can build tolerance of it. A high genetic aspect can be countered by a “low hygienic” environment according to research.

Well, in digging into some research papers, I found “mast cell activation can be caused by both IgE-mediated and non–IgE-mediated triggers”.

This is because there can be a mast cell mutation (KIT) which then doesn’t require IgE for activation. You have MMAS and not Mastocytosis, right? The mutation seems to be associated with Mastocytosis based on my understanding from the paper.

Since mast cells aren’t privileged, they’re restricted from entering sites like the brain and spinal cord. So, if they’re in the spinal cord, you almost certainly have bigger problems than mast cell activation I’d think, as the barrier isn’t doing it’s job.

In case you’re interested, here’s the paper on mast cell disorders: https://www.jacionline.org/article/S0091-6749(17)31025-4/fulltext

Here’s one on the brain and spinal cord: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481533/

The BIGGEST issue with our understanding of the immune system today is that ALL testing is done on mice. The human body on a chip technology along with the digitization of the immune system together will be a monumental step. Thankfully, it’s literally something we’ll have in the near future. Once that’s available, we’ll have human specific data plus an onslaught of constant information, which we need to help folks with all of the immune system disorders. I’m an autoimmune patient and losing my friends and family to this uncertainty has led me into the field to try and help improve our understanding. There’s legit more we don’t know than we do know about the human immune system right now.

While there’s no free floating IgE in your system, to degranulate mast cells need IgE bound to their surface. Thats the activation aspect. Since you need mast cells, it’s not exactly something you can turn off. Glad you know the triggers at least, gives you the opportunity to make moves accordingly!

Here’s a great image of degranulation:

You need two IgE’s to cross-link the same antigen as well, like what is shown above.

Yep! Mast cells are activated when IgE antibodies bind to a mast cell receptor. When IgE then binds to the one object it was designed to find, you get mast cell degranulation. This releases histamines along with a few other chemicals. Degranulation is our immune defense against parasites, so you got a head start for parasite defense for sure! But desensitization can be achieved, which makes IgG antibodies bind to the foreign object before IgE has the chance. I’d think this could be a possible treatment for the syndrome.

Do you also have asthma? The same IgE’s also bind to eosinophil’s. Mast cell degranulation in the lungs leads to acute asthma, whereas when eosinophil’s join the party it causes airway remodeling, aka chronic asthma.

It’s no picnic, parasites are burly! The Th2 adaptive immune response for worms, our only parasite response, is only good with small initial infections. But since the side effects are relatively mild considering all parasites, it’s not a big area of focus.

Fun fact: The same response for parasites causes allergies. You can never be allergic when it’s your first exposure either. But a less hygenic environment as a kid greatly redices the risk of developing allergies.

Of course!

• This ones about the evolutionary benefits: The origin of risk aversion https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273387/

• Here’s one on fatal motorcycle accidents: Increased risk of traffic accidents in subjects with latent toxoplasmosis - a retrospective case-control study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC117239/

• For good measure, here’s one on business owners and the parasite: Risky business - linking Toxoplasma gondii infection and entrepreneurship behaviours across individuals and countries https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083268/

Toxoplasmosis is very intriguing, it has actually evolved alongside cats and humans for ages. While anyone with an immunodeficiency is at higher risk of severe side effects, like with any pathogen, it’s also associated with taking bigger risk. This is why a ton of motorcyclists and casino regulars test positive for the parasite. But when we were hunter gatherers, the infection was associated with bringing home bigger kills, which helped the entire tribe. Due to this, toxoplasmosis infections had sizable benefits and those with the infection often had positions of power in tribes!

Aegis is my absolute favorite for 2FA’s, give it a try for sure. Pretty sure it’s only available on Android unfortunately though.

Use latlong.net/convert-address-to-lat-long.html, life saver with osmand+!

I’ve never noticed this, I’d bet it’s associated with your notification settings. My only gripe is that everytime my phone restarts, I have to open the app and reselected the ask first option for calling. Otherwise the number I don’t use associated with my service plan will be what I call from :/

I’m in this field to help anyone who’s willing to listen. Makes me stoked to know I was able to assist with your struggle. Be well and take care of yourself!

Glad to hear it!

Interesting! Makes me think of H. pylori as, even while the pathogen resides only within the GI tract, it’s presence has been associated with many diseases. This is primarily due to inflammation, but its OMV secretions as well as molecular mimicry too.

Well it functions in both blood filtration and for blood/immune cell storage, both of which are critical for staying alive and reproduction. But when it comes to evolution, things aren’t always straight forward. Maybe there was a entirely different function which had a bigger positive impact on overall fitness and since the spleen situation didn’t decrease fitness, it too was past along.

With the original Beeper app you made an Apple ID through Apples website to use for setting up iMessage. This does require folks having the email in order to use iMessage, so definetly worth setting up an alias. It still works, while Beeper Mini doesn’t apparently.

Ya, implying recommending FOSS options is an involuntary action was tongue-in-cheek.